Monophosphoryl lipid A is an adjuvant derived from a bacterial endotoxin, one of the most potent immunostimulants known. MPL Product Detail Cervarix HPV Vaccine Bivalent Recombinant Types 16 and 18 “The adjuvant system, AS04, is composed of 3-O-desacyl-4’-monophosphoryl lipid A (MPL) adsorbed on to aluminum (as hydroxide salt). Adjuvant patents October 26,