ilotycin Generic Name: erythromycin Dosage Form: ophthalmic ointment
July 1, 2019 – The hepatitis B birth‐dose immunisation: Exploring parental refusal “One hundred and thirty‐seven of the 1574 (8.7%) eligible reviewed infants had HBV immunisation birth‐doses documented as declined; 113 mothers consented to complete the questionnaire. The most common reasons for declining the dose were: ‘baby too young’ (55.8%); preference for two, four and six‐month HBV immunisations only (56.6%); perceived low risk of contracting HBV (45.1%); and a fear of ‘overloading’ their baby’s immune system (42.5%).”
February 2018 – The Contribution of Neonatal Jaundice to Global Child Mortality: Findings From the GBD 2016 Study “In some infants, NNJ may become severe enough to put them at risk for bilirubin-induced mortality or long-term neurodevelopmental impairments necessitating effective evaluation and treatment.”
July 2017 – Variations in Cause-of-Death Determination for Sudden Unexpected Infant Deaths “For 3 scenarios portraying potential airway obstruction and negative autopsy findings, 61% to 69% classified the death as suffocation/asphyxia. In the last scenario, which portrayed a healthy infant in a safe sleep environment with negative autopsy findings, medical examiners and coroners classified the death as sudden infant death syndrome (38%) and SUID (30%). Reliance on investigative procedures to determine cause varied, but 94% indicated using death scene investigations, 88% full autopsy, 85% toxicology analyses, and 82% medical history review. CONCLUSIONS: US medical examiners and coroners apply variable practices to classify and investigate SUID, and thus, they certify the same deaths differently. This variability influences surveillance and research, impacts true understanding of infant mortality causes, and inhibits our ability to accurately monitor and ultimately prevent future deaths. Findings may inform future strategies for promoting standardized practices for SUID classification.
June 24, 2017 – Cardio-Respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants < 32 Weeks Gestational Age: A Randomized Controlled Study. “Results: In the placebo group, immunization was associated with significantly increased CRP levels and an increase in CRE (8.6 +/- 11.1 before vs. 14.0 +/- 12.8 after) which did not reach statistical significance (p=0.08), and no change in PgE2. The increase in CRP was correlated with changes in CRE (r=0.4, p<0.05). In the ibuprofen group, immunization significantly increased CRP levels but was not associated with change in CRE (6.7 +/- 7.7 before vs. 6.8 +/- 9.7 after) and PgE2 levels. Comparing the groups, variation in CRE ([DELTA]CRE before vs. after immunization) was significantly lower in the ibuprofen group (0.1 +/- 7.9 vs. 5.4 +/- 10.0 [DELTA]CRE, p<0.05).”
June 8, 2017 – Reduced antibody response to infant measles vaccination: effects based on type and timing of the first vaccine dose persist after the second dose “As previously noted among infants born to mothers with history of wild-type measles, antibody responses among children born to vaccinated mothers were reduced based on earlier administration of their first measles vaccine dose at ≤12 versus ≥15 months of age. Negative effects of earlier age at first measles vaccine dose persisted after the second dose. The measles elimination goal may require a careful balance between earlier infant protection and the risk of reduced antibody responses and secondary vaccine failure among successive birth cohorts systematically initiated to measles vaccination below 15 months of age.”
September 14, 2015 – Are Pediatricians Complicit in Vitamin K Deficiency Bleeding? “When parents ask for a vitamin K preparation of unproven effectiveness, should the clinician honor that request? To address these questions, we present a case of a healthy newborn whose parents declined intramuscular vitamin K and requested an oral preparation. Two general pediatricians discuss the medical and ethical issues these situations pose, and the parents describe their experience.”
September 3, 2015 – Dangers of death on the first day of life by the minute “Conclusion: Infant mortality is highest on the first day of life. More focus on prematurity and birth asphyxia in the first 5 h of life is needed to improve infant mortality.”
August 27, 2014 – Reevaluating HIV Vaccine Clinical Trials Policy for Infants (full text) “As such, the development of an effective HIV vaccine administrated either prenatally or during the neonatal period may be a very useful intervention to eliminate infant acquisition of HIV.”
August 20, 2014 – The association between age and the development of respiratory syncytial virus neutralising antibody responses following natural infection in infants “The disease incidence estimates presented in Fig. 1b, suggest that in order to have the greatest impact on disease burden, infants should be vaccinated prior to the period of greatest risk of disease, at about 2 months of age. However the poor response to natural infection in infants under the age of 4 months suggests that such infants are unlikely to mount strong neutralising antibody responses to live vaccines. Nonetheless, the data presented suggest that vaccination of infants aged 4 months and above is likely to provide substantial benefit. To protect very early infants at the period of greatest risk, there is need to explore alternative strategies such as maternal vaccination. The boosting of the titre of trans-placentally transferred antibody will increase the duration of infant protection and delay the age of first infection, at which time infection is less likely to result in severe disease. Comment: So keep using the status quo vaccines with their reactogenicity on poor defenseless infants? There isn’t any guarantee once these new vaccines go into trials, or postmarketing trials they will be safe.
September 11, 2011 – Silver Nitrate And Prophylactic Eye Ointments For Newborns
Side Effects:
- Silver nitrate bonds with the eye membranes which results in redness, blurred vision, and swelling for several days.
- Early visual perception development is altered which impacts the baby’s ability to adjust to the world outside the womb.
October 2010 – Ilotycin Side Effects Center “Ilotycin (erythromycin) Ointment is an antibiotic used to treat superficial ocular (eye) infections, and to prevent neonatal gonococcal or chlamydial conjunctivitis. The brand name Ilotycin is discontinued, but generic versions may be available. Common side effects of Ilotycin (erythromycin) Ointment include:”
September 10, 2009 – Erythromycin Ophthalmic Ointment Shortage FDA
April 2006 – Delayed cord clamping in very preterm infants reduces the incidence of intraventricular hemorrhage and late-onset sepsis: a randomized, controlled trial (full text) “Delayed cord clamping seems to protect VLBW infants from IVH [intraventricular hemorrhage] and LOS [late-onset sepsis], especially for male infants.”
February – Trends in Hospitalizations for Neonatal Jaundice and Kernicterus in the United States, 1988–2005 “Trends in diagnosis for newborn jaundice were u-shaped, with rates falling in the years before the initial American Academy of Pediatrics guideline (1988–1993) and increasing in the years after publication of the guideline (1997–2005).”
June 1998 – Length of Stay, Jaundice, and Hospital Readmission “Discharge at any time <72 hours significantly increases the risk for readmission to hospital and the risk for readmission with hyperbilirubinemia when compared with discharge after 72 hours.’