http://www.cdc.gov/mmwR/PDF/rr/rr5515.pdf

Precautions

Temperature of >105°F (>40.5°C) for <48 hours after vaccination with a previous dose of DTP or DTaP
Collapse or shock-like state (i.e., hypotonic hyporesponsive episode) <48 hours after receiving a previous dose of DTP/DTaP Seizure <3 days after receiving a previous dose of DTP/DTaP¶ Persistent, inconsolable crying lasting >3 hours within 48 hours after receiving a previous dose of DTP/DTaP Guillain-Barré syndrome (GBS) <6 weeks after previous dose of tetanus toxoid-containing vaccine Moderate or severe acute illness with or without fever Temperature of <104°F (<40.5°C), fussiness, or mild drowsiness after a previous dose of diphtheria toxoid-tetanus toxoid-pertussis vaccine (DTP/DTaP) Family history of seizures¶ Family history of sudden infant death syndrome Family history of an adverse event after DTP or DTaP administration Stable neurologic conditions (e.g., cerebral palsy, well-controlled seizure disorder, developmental delay)

http://www.rxlist.com/cgi/generic2/tripedia_ad.htm

Dow Chemical Company’s DPT product insert in the 1960’s states: “fractional doses are recommended in infants with cerebral injury, asthma, a strong family history of allergy…”  In 1961, Hooper found that in a group of babies who reacted violently to the pertussis vaccine, there was twice as much eczema, asthma, hay fever, and allergic skin rashes in the child, his brothers and sisters, parents, and grandparents as there was in a control group of the same size.  In 1969, Hannik found a positive family history of allergies in a significant proportion of infants who reacted with high pitched screaming, shock and convulsions.

http://pediatrics.aappublications.org/cgi/content/abstract/73/1/31

One hundred children received a half dose of DTP vaccine because of a less serious reaction associated with prior immunization. In all instances, they had significantly less serious local reactions as well as notable differences in temperature, drowsiness, and persistent crying.

A 1982 study by Stienman concludes that genetic predisposition may play a role in pertussis vaccine reactions and suggests that a personal or family history of allergies, particularly milk allergy, may be a warning sign.  Steinman’s work has been reinforced by reports from parents whose children are allergic to milk and have reacted to the vaccine.  An allergy to milk may be manifested by severe constipation, diarrhea, projectile vomiting or frequent spitting up of significant amounts of milk after bottle or breast feeding, persistent crying after feedings (colic), eczema or recurrent skin rashes.

Aust Fam Physician 1976 Jul;5(6):734-55 Over-immunization-an ever present problem. Trinca JC.

The development of purified vaccines for the control of common infectious diseases may lead to a sense of false security and a tendency to over-immunize. Repeated antigenic challenge may cause hypersensitivity reactions which could harm the individual. For each vaccine there is an opitmum time and age for dosing; for those vaccines requiring a course of doses, there is a minimum but no maximum time interval between the doses. In Australia, active immunization is conducted on a regular basis against seven preventable infectious diseases. In this article, the vaccine control each disease is discussed briefly andsuggestions made to avoid hyperimmunization. The need to appreciate the dangers inherent in all immunization procedures in general, and in certain vaccines in particular, is emphasized.Indescriminate immunization cannot be condoned

“Parents should decide through informed choice, which vaccines if any should be given to their children”

August 1958 – ECZEMA VACCINATUM – 1) No child with atopic eczema or other skin disorder should be vaccinated. 2) No child should be vaccinated if any member of his family has eczema or other skin disorder. 3) Parents of children with eczema should be notified at the onset of the disease of the danger from vaccination contact. 4) If a sibling of a child with atopic eczema is vaccinated, he must be completely separated from that child for at least 21 days. 5) Forms used by state and local health departments for parents’ consent to vaccination should include an appropriate warning of the contraindications. 6) Eczema vaccinatum should be a reportable disease. 7) Patients recently vaccinated must be excluded from pediatric wards containing patients with atopic eczema, other diseases of the skin, burns or healing surgical incisions. 8) Vaccination may be recommended at 2 months of age, especially for babies from strongly allergic families.”

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